effect of the aerobic training and antioxidant supplementation on the cellularity of the femur bone marrow in rats exposed to lead acetate

bone marrow is a primary source of various kinds of blood cells and, thus, is frequently used for evaluation of therapeutic agents. the influence of physical regular training and curcumin supplementation on the cellularity of the femur bone marrow was investigated in rats exposed to lead acetate. 48 the wistar rats were randomly assigned to one of the six groups include; 1)base, 2)sham-operate, 3)lead acetate, 4)aerobic training+lead, 5)curcumin+lead supplementation and 6)aerobic training+curcumin+lead group (n=8 per group). the 3 to 6 groups received lead acetate (20 mg/kg) only, while the 5 and 6 groups also, received (30 mg/kg) curcumin supplemention peritoneally 3 days in week for 8 weeks. furthermore, rats in the 4 and 6 groups performed the progressive running exercise of 15 to 22 m/min for 25 to 64 min, 5 times a week. bone marrow cellularity was measured by the image analyzing system and determined by the percentage of cellular marrow. furthermore, malondialdehyde (mda), total antioxidant capacity (tac) and lead level were measured by tbars, elisa and spectrophotometry methods in blood, respectively. data was analyzed by one-way anova test and tukey at p